Endothelial to Mesenchymal Transition in Cardiovascular Disease
نویسندگان
چکیده
منابع مشابه
Epithelial-to-mesenchymal and endothelial-to-mesenchymal transition: from cardiovascular development to disease.
Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a mesenchymal-toepithelial phenotype, are important biological programs that are operative from conception to death in mammalian organisms. Indeed, the capacity of cells to switch between these states has been fundamental to the generation of complex body patterns throughout evolution. Phenotypic switching from ...
متن کاملBasic Science for Clinicians Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition From Cardiovascular Development to Disease
Cellular switching from an epithelial-to-mesenchymal phenotype, and conversely from a mesenchymal-toepithelial phenotype, are important biological programs that are operative from conception to death in mammalian organisms. Indeed, the capacity of cells to switch between these states has been fundamental to the generation of complex body patterns throughout evolution. Phenotypic switching from ...
متن کاملEndothelial-to-mesenchymal transition in pulmonary hypertension.
BACKGROUND The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle actin-expressing cells. METHODS AND RESULTS In situ evidence of EndoMT in hu...
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The molecular mechanisms responsible for the development and progression of atherosclerotic lesions have not been fully established. Here, we investigated the role played by endothelial-to-mesenchymal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis. In cultured human endothelial cells, both inflammatory cytokines and oscillatory shear stress reduced endothelia...
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Owing to this fact that most of the mortalities in cancers are as a result of metastasis, study on the involved pathways in metastasis including Epithelial to mesenchymal transition (EMT) would be so critical and important. Up to date, several extensive studies have been carried out to determine the correlation between EMT and cancer and their results have shown that the EMT plays pivotal role ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2019
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2018.09.089